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In addition, other natural products such as curcumin, shikonin derivatives, vitamin D and pulsatilla saponin D, have been shown to suppress multiple DDR pathways and sensitize cancer cells to PARP inhibitors [257,258,259,260,261]

Targeting lysophosphatidic acid receptor with Ki16425 impedes T-cell lymphoma progression through apoptosis induction, glycolysis inhibition, and activation of antitumor immune response

Vehicle IGF-1 (5 nM) or IGF-2 (20 nM) was then added to the media for 2 min and cells were then rapidly lysed in ice-cold buffer to assess receptor activation as described below