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Although early findings are encouraging, the majority of available evidence is derived from laboratory and animal research

Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

Why Formulation Quality Determines Whether These Ingredients Actually Work GHK-Cu and retinol are only as effective as the formulation delivering them

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