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5.1 Iron chelators and iron modifiers Iron chelators and modifiers effectively inhibit cellular ferroptosis by regulating the expression and activity of iron transporters and storage proteins, including transferrin and its receptor (TfR1), ceruloplasmin, ferroportin, divalent metal transporter 1 (DMT1), and other membrane iron transport proteins (24, 26)

Of interest, eCBs levels did not differ in these two subgroups of patients, indicating that elevations of CSF eCBs are independent of disease duration

Price: $420/month Administration: Subcutaneous injection, once daily, self-administered at home Loading dose: 2 mg daily for week 1 Maintenance dose: 4 mg daily from week 2 onward Recommended duration: 8 to 12 weeks (minimum 4 weeks to assess response) Includes: Clinical consultation, pharmaceutical-grade peptide, bacteriostatic water, injection supplies, provider access Available via: In-person (Lincoln Park) or telehealth (Illinois statewide) Patients often ask how ReWire fits alongside other peptide protocols