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SAT1 was demonstrated to induce ferroptosis by elevating the expression of arachidonate 15-lipoxygenase (ALOX15)[42]

For most grade 2 toxicities, consider holding ICIs and resume when symptoms and/or laboratory values recover to grade 1 or less

Furthermore, a substantial proportion of studies rely on single-laboratory models without independent replication, which raises concerns about reproducibility and robustness across experimental settings