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[20] The neuronal circuitry affected by LTP/LTD and modified by scaling and metaplasticity leads to reverberatory neural circuit development and regulation in a Hebbian manner which is manifested as memory, whereas the changes in neural circuitry, which begin at the level of the synapse, are an integral part in the ability of an organism to learn

Inflammatory markers such as IL-2, IL-6, IL-7, IL-10, IL-18, interferon (IFN)-, monocyte chemoattractant protein (MCP)-1, MCP-3, and macrophage-inflammatory protein-1 have been associated with symptom severity [54-56]