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In summary, the three antioxidant systems Xc -GSH-GPX4, FSP1-CoQ 10 -NAD(P)H, and GCH1-BH 4 can scavenge lipid peroxides during ferroptosis

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We discuss the failure of previously tested antioxidants, neuroprotective agents, anticonvulsants and antidepressants as therapeutic or preventative strategies, and suggest individualized, mechanism-based therapeutic options for CIPNP associated with each of the three main drug groups

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