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Brooks SC, Locke ER, Soule HD (1973) Estrogen receptor in a human cell line (MCF-7) from breast carcinoma

This approach mirrors dosing strategies used for other peptides with 1216 hour half-lives, though published 5-amino-1mq pharmacokinetic data in humans remains limited

Mechanistically, PA reduces the expression of GPX4 and heat shock factor 1 and regulates the transcription of genes related to iron metabolism (such as FTH, TFR1, and SLC40A1), causing iron homeostasis imbalance, while GPX4 overexpression reverses PA-induced ferroptosis in cardiomyocytes