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When the continuous increase in cytoplasmic Ca2+ causes the cell to round up and the plasma membrane to completely collapse, the cell's repair mechanisms become overwhelmed, leading to membrane rupture

His death on Sunday in a Mexican military operation in Tapalpa, in the western coastal state of Jalisco, has triggered widespread unrest across parts of the country

Considering the putative role of oxidative stress as a pathogenetic factor for the development of colitis and because the reductive metabolism of TNBS has been shown to generate ROS, this model of colitis was chosen to evalute the temporal relationship between the levels of GSH in mucosa and the appearance and extent of injury in vivo during the acute phase of colitis in TNBS+ethanol-treated rats and to determine the effect of NAC administration on mucosal GSH levels and extent of injury

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