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HRT hormone replacement therapy IHC immunohistochemistry iod integrated optical density IPA Ingenuity Pathway Analysis iTRAQ isobaric tag for relative and absolute quantitation KEGG Kyoto Encyclopedia of Genes and Genomes LC liquid chromatography MDA malondialdehyde MRM multiple reaction monitoring MS mass spectrometry OVX ovariectomized PBS phosphate-buffered saline PLS partial least squares regression analysis qRT-PCR quantitative reverse transcriptase polymerase chain reaction SOD superoxide dismutase TBS-T triethanolamine-buffered saline solution containing Tween TOF time of flight UA uric acid WB western blot References 1 AhmedS

3 -TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

it may act as a beneficial, Met-induced metabolic hormone in adults while being deficient in some adolescent populations