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The implication for clinical practice is that restoring youthful MOTS-c signaling might be a mechanistically legitimate target for longevity intervention

The areas of interest are the effects on glycemia, body weight, and cardiovascular risk markers

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A phase III study (COSMIC-313) of cabozantinib (C) in combination with nivolumab (N) and ipilimumab (I) in patients (pts) with previously untreated advanced renal cell carcinoma (aRCC) of intermediate or poor risk