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Notably, platelet production follows a circadian rhythm, peaking in the late night and early morning, coinciding with the timing of adverse cardiovascular events ( In epilepsy, administering a higher evening dose of clobazam has been shown to improve seizure control in patients whose seizures occur predominantly at night or in the early morning

Reinke SN, Naz S, Chaleckis R, Gallart-Ayala H, Kolmert J, Kermani NZ, et al