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In cell-based and animal studies, GHRH-receptor agonism (tesamorelin) and GHS-R1a agonism (ipamorelin) have been reported to engage different intracellular signaling cascades that both terminate in growth-hormone secretion, an arrangement investigators have explored for potentially amplified, rather than simply additive, secretory responses

IUBMB Life 67:659667 Maubant S, Tesson B, Maire V, Ye M, Rigaill G, Gentien D, Cruzalegui F, Tucker GC, Roman-Roman S, Dubois T (2015) Transcriptome analysis of Wnt3a-treated triple-negative breast cancer cells

So far, in vivo methods for determination of Nrf2 activity have been established in zebrafish strains 34,35,36 , in vitro methods using mammalian cells are described 37,38,39,40 , and standardized high-throughput assays in human cell lines 41 have been developed