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The skin has unique characteristics: It is permeable relative to the environment and allows the diffusion of air, heat, water, and low molecular weight molecules [145]

Plant Physiol Biochem 48(12):909930

As will be discussed, one mechanism which may connect thiol-metal binding to oxidative stress-mediated toxicity is specific of Hg, the cysteinyl-glycine bound form of which is able to deplete glutathione reservoirs by a catalytic process [34]

The presence of fibrosis was negatively associated with SOCS3 gene promoter methylation and positively associated with mRNA expression of SOCS3, TXNIP, IL-6, and MCP-1, which are involved in oxidative stress, inflammation, and fibrogenesis [335]