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Diabetes Care 28 , 956962 (2005)

FIGURE 6 Although in vitro experiment indicated TMZ showed exacerbate effect on UA induced cardiomyocytic injury, the in vivo experiment showed an opposite tendency

115 Hyperglycemia induces vascular calcification via AGE accumulation, leading to hydroxyapatite deposits in both the intimal and medial layers, characteristic of atherosclerotic plaques and medial arterial calcification