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A few of the fundamental biological reactions NAD+ facilitates are: Energy Production: NAD+ assists your cells in converting food to energy by operating as an electron transporter during cell metabolism Gene Expression: Certain enzymes can turn off genes that promote aging, such as those that are involved in inflammation, fat synthesis and storage, and blood sugar management

Exposure of astrocytes to Fe2 + resulted in increased Nrf2 time- and concentration-dependent expression, whereas knockdown of Nrf2 levels by siRNA resulted in greater toxicity of Fe2 + -induced astrocytes (Shin et al., 2019