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Abstract Introduction: Paclitaxel, a widely used chemotherapeutic agent for various cancers, induces peripheral neuropathy (PIPN) in approximately 80% of patients, severely affecting their quality of life

Data availability Mass spectrometry proteomics data have been deposited in ProteomeXchange Consortium via the PRIDE partner repository under the accecssion code PXD021305

GuoSCzarez-MrquezFJiaoHFoppenEKorpelNLGrootemaatAEet alSpecific silencing of microglial gene expression in the rat brain by nanoparticle-based small interfering RNA delivery

Nevertheless, the 2.9-fold increase in ET levels after 28 days of administration relative to controls, suggests a slow but gradual accumulation of ET, with no certainty that a peak was reached in this time