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This mutation does not affect the amino acid sequence, but does alter mRNA splicing in favor of transcripts lacking exon 7 [12][17]

doi: 10.3389/fmolb.2022.964624 Received 08 June 2022 Accepted 11 July 2022 Published 26 August 2022 Volume 9 - 2022 Edited by Giuseppe Calamita, University of Bari Aldo Moro, Italy Reviewed by Umberto Laforenza, University of Pavia, Italy Paul Yancey, Whitman College, United States Updates Copyright 2022 Ilyas, Wijayasinghe, Khan, El Samaloty, Adnan, Dar, Poddar, Singh, Sharma and Khan

In some patients with somnolence (approximately one-half), there was associated reduced nutritional intake and weight loss