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3) Downregulation of GPX4 occurs even in presymptomatic stages of disease in mouse models (368, 371)

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Caspase-1 inhibitors (e.g., Ac-YVAD-CMK, VX-765) can alleviate pulmonary vascular remodeling, reduce right ventricular systolic pressure in MCT-induced PH rats, and significantly reduce the level of pulmonary fibrosis [134]