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Description

However, this increased phosphorylation of AKT is not due to PTPN22 phosphatase activity, as pharmacological inactivation of PTPN22 activity by treating cells with the PTPN22 inhibitor (PTPN22-IN-1) does not affect AKT phosphorylation

A pharmaceutical composition according to claim 4, wherein the compound has the structure of formula (V): wherein: R 1 is selected from the group consisting of aryl, C 1-6 alkyl-aryl, and C 3-10 carbocycle, wherein the aryl, C 1-6 alkyl-aryl, and C 3-10 carbocycle may be optionally substituted with an atom or a group selected from the group consisting of halo, deuterium, C 1-6 alkyl, CF 3 , and combinations thereof