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The activation of the cGAS/STING pathway causes ROS accumulation and mitochondrial damage and promotes the migration and invasion of RA-FLSs, a process associated with the activation of the Hippo pathway

This is supported by the fact that several ME/CFS outbreaks have occurred in the same geographical region simultaneously (100) in the Faroe Islands during World War II upon the arrival of foreign army corps, and was eventually shown to be due to EBV (101)

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This study provided concrete, mechanistic proof that replenishing the serotonin pathway can support the management of post-viral neurological symptoms