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(Outlines contraindications for niacin therapy, including active peptic ulcer disease, active liver disease with elevated enzymes, hypersensitivity to niacin, and arterial bleeding, as well as monitoring recommendations for blood pressure, glucose, uric acid, etc., due to niacins systemic effects)

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However, as noted above, their fat loss evidence is limited, their UK legal status for human use is not established, and the safety data is insufficient to recommend them as a complement to legitimate weight loss treatment