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Target enzymes in serine-glycine-one-carbon metabolic pathway for cancer therapy

3,4 Dysfunctions in this system contribute not only to digestive disorders but also to obesity, diabetes, autoimmune conditions, and neuropsychiatric diseases, underscoring the profound importance of GI health in both preventive and therapeutic medicine

A prominent increase of protein adducts leading to hepatotoxicity was observed in the pericentral region due to low GSH concentration and sulfation activity

A recent study reported that egl nine homolog 1 (EGLN1) and Myc activate lymphoid-specific helicase (LSH) expression through HIF-1, and that LSH suppresses ferroptosis through the interaction with WDR76, leading to the activation of lipid metabolism-associated genes (Miess et al., 2018)