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In addition, acylcarnitine accelerates the degradation of the PD1 protein by promoting the acetylation of the E3 ubiquitin ligase FBXO38, revealing not only the mediating role of acylcarnitine in mitochondrial communication between platelets and B cells but also its epigenetic regulatory role in regulating mitochondrial function and PD1 degradation [43]

This phenomenon can be reversed by l-Carnitine through attenuating the p47Phox level, which leads to the detection of a decreased cytosolic ROS level through the DCFDA reaction under a fluorescent microscope (Fig

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