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Although the anti-seizure drugs (ASDs) lamotrigine (15 mg/kg), levetiracetam (40 mg/kg), carbamazepine (40 mg/kg), and phenytoin (35 mg/kg) could not suppress generalized tonic-clonic seizures in pentylenetetrazole-kindled mice, administration of a taurine supplement (50, 100 & 200 mg/kg) with ASDs restored the anti-seizure effect of tested ASDs [113]