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This work was supported by the Defense Threat Reduction Agency under the Rapid Assessment of Platform Technologies to Expedite Response (RAPTER) program (award no

As you age, NAD levels naturally decline, and this is closely linked to mitochondrial dysfunction, impaired DNA repair, decreased cellular resilience, and the onset of age-associated conditions, ranging from cognitive decline to metabolic disorders

The activity was measured as indicated above, all three biological replicates ( n =3) consisting of independent plant material were individually measured as three technical replicates

The experimental protocol was designed as follows: When the tumor volume reached ~100 mm, the tumor-bearing mice were Five groups ( n = 6 per group) receiving PBS control, Psa-AR, enzalutamide monotherapy, pimitespib monotherapy, or enzalutamidepimitespib combination therapy were randomly assigned