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TABLE 2Active metabolites developed as drugsMetabolite drugs Parent drugsAcetaminophen PhenacetinCetirizine HydroxyzineDesimipramine ImipramineDesloratadine LoratadineDigoxin -methyldigoxinFexofenadine Terfenadine (withdrawn due to cardiotoxicity)Mesoridazone ThioridazoneMorphine CodeineNortriptyline AmitriptylineOxazepam DiazepamPhenobarabital PrimidoneN-Acetylprocainamide Procainamide (A