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(2020) and later De Ruyck et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Altmann R

This Mn effect on YY1 could be closely associated with Mn-induced excitotoxic neuronal injury as reduction of GLT-1/GLAST would accumulate glutamate in the synaptic clefts and overstimulate its receptors

The relationship between viral infections and immune dysfunction thereby supports the hypothesis that ME/CFS arises from an initial infection which leads to persistent immune dysregulation