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Evidence and risk depend on the molecule, indication and stage of research

They are not a replacement for a healthy lifestyle, but they may be a helpful addition to a broader plan

Of the two potential mechanisms that could account for the constructive interaction between DHEAS and E 2 17G, namely, cotransport of DHEAS and E 2 17G from a single substrate binding site or that DHEAS stimulates E 2 17G transport by binding to a topologically distinct site on the protein, we favor the latter possibility based upon the observations that the stimulatory interaction between DHEAS and E 2 17G is not reciprocal and that stimulation of E 2 17G transport was attenuated at high DHEAS concentrations