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Notably, the microsomal GSSG levels were only very modestly decreased following BSO exposure (Fig

Adverse events were classified by severity as mild (easily tolerated, causing minimal discomfort, and not interfering with everyday activities), moderate (causes sufficient discomfort and interferes with normal everyday activities), or severe (prevents normal everyday activities)

Additionally, standardizing light irradiation doses in multi-center trials is challenging, in which variations in equipment, duration, and intensity reduce result comparability, hampering unified clinical standards. Notably, clinical experience with second-generation photosensitizers such as ALA in treating condyloma acuminatum, encompassing administration protocols, irradiation parameters, and efficacy assessment, provides a valuable reference for the design of subcellular PDT