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According to a 2013 research review, alcohol is technically a toxin

However, malnutrition and starvation are difficult to assess clinically and in particular protein-calorie malnutrition can co-exist with chronic alcohol use and with inter-current acute or chronic illness, which may independently or in concert increase the risk of paracetamol toxicity and confound the assertion that malnutrition per se increases the risk of paracetamol toxicity [6, 16, 73, 78,79,80,81,82,83]

92nd Annual Clinical Congress of the American College of Surgeons

This paradox drives intensive research on molecular targets including IL-5/IL-5R, IL-4(R)/IL-13, TSLP, IL-33, and ST2 for precision therapies ( Nevertheless, developing multi-mechanism therapeutic strategies remains imperative, particularly targeting concurrent inflammation and airway remodeling