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Conjugation reactions usually involve metabolite activation by a highenergy intermediate and have been classified into two general types: type I (e.g., glucuronidation and sulfonation), in which an activated conjugating agent combines with substrate to yield the conjugated product, and type II (e.g., amino acid conjugation), in which the substrate is activated and then combined with an amino acid to yield a conjugated product (Hodgson, 2004)

212214 Alpha-enolase, a glycolytic enzyme expressed in most tissues that plays a role in many cell functions, has been identified as an autoantigen in Hashimotos encephalopathy

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mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function