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Ectopic expression of SLC25A39 promotes LUAD malignant progression To investigate the functional role of SLC25A39 in LUAD cells, A549 and H1299 cells were transduced with a lentiviral vector encoding SLC25A39 (oeSLC25A39) or a control empty vector (Vec), followed by selection of stable cell lines using puromycin

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Results Tumor cells outcompete T cells for cystine uptake, leading to T-cell exhaustion and death Firstly, we compared the capability of cystine uptake between T cells and tumor cells, confirming that SLC7A11 , the functional subunit of system Xc-, was upregulated in various human tumors (Supplementary Fig

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