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Ponte LGS, Pavan ICB, Mancini MCS, da Silva LGS, Morelli AP, Severino MB, et al

Under these conditions, glutamine metabolism becomes essential for maintaining cellular redox homeostasis by harnessing enhanced ROS levels

In contrast, anaplastic astrocytomas and IDH wild-type GBMs also harbor these mutations but have varying prognostic outcomes

For instance, in several clinical and preclinical studies, SF counteracts several molecular abnormalities associated with autism spectrum disorder (ASD) that address reduced antioxidant capacity, enhanced oxidative stress, deficient glutathione synthesis, mitochondrial dysfunction, increased lipid peroxidation, and neuroinflammation (2)