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Ultimately, P4HB-K311la exacerbates cardiac injury in RIHD through the PTGS2/SH3GLB1/NDP52 pathway, worsening RIHD progression

DOI: 10.1158/1535-7163.MCT-18-0529 Mol

Lack of Nrf2 can increase the sensitivity and severity of different respiratory conditions such as BPD, adult respiratory distress syndrome, chronic obstructive pulmonary disease, asthma, and lung cancer, whereas activation of Nrf2 protects against various respiratory diseases (47)

CKD induces microbial dysbiosis, which compromises the intestinal mucosal barrier and allows harmful bacteria and uremic toxins to enter the bloodstream