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Furthermore, some researchers have used nano-cascade engineering to construct metal-organic supermolecules with p53-activating peptides and CeO 2 nanoparticles, which can activate the p53 signaling pathway and down-regulate the downstream gene GPX4 in vitro and in vivo, thereby inhibiting the development and progression of lung cancer [106]

Ahmadi, M., Keshavarz, S

IGF1R was subsequently identified as a putative target of miR-503 via bioinformatic analysis and, then experimentally validated via western blot analysis and luciferase assay