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Accordingly, the SLC1A2 gene that encodes the astrocytic excitatory amino acid transporter 2 (EAAT2, responsible for majority of glutamate re-uptake in the brain) is a susceptibility locus to BD (Fiorentino et al., A relationship was found between glucose metabolism and glutamatergic neuronal function in vivo in the rat cortex by measuring the rates of TCA cycle and glutamate synthesis using 14 C-MRS (Sibson et al., 1998)