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Peter Howard will perform a thorough evaluation to confirm the diagnosis

In vitamin B12 deficiency, the accumulation of methylmalonyl coenzyme A and malonyl coenzyme A, leads to the synthesis of single-chain fatty acids that are incorporated into the nerve sheath, resulting in myelin changes

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Cuprizone model of toxic demyelination C57BL/6 mice are fed with cuprizone for 6-10 weeks to induced widespread demyelination, especially in the splenium of the corpus callosum