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Surprisingly and in contrast to the IgG C H 1 domain, we observed that glycosylated C H 1 could not be folded by 5 but only by the SLC in vitro with a rate constant = 66 min, whereas unglycosylated CH1 required = 104 min, indicating that glycosylation accelerates C H 1 folding by SLC (Supplementary Fig

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Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance