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The lower initial infusion would allow for immediate treatment in suspected acute liver failure from overdose cases to prevent delay while awaiting serum paracetamol levels and liver function tests

Cerretani D, Collodel G, Brizzi A, Fiaschi AI, Menchiari A, Moretti E et al

Furthermore, the combination of BMS-754807 and U0126 efficiently decreased the cell viability and increased cleaved caspase 3 and apoptosis in vitro and in vivo