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MI/R notably elevated the activity of creatine kinase (CK), intensified oxidative stress, diminished the activity of antioxidant enzymes, and facilitated apoptosis and inflammation in a time-dependent manner

An overview of the major genetic disease patterns associated with primary mitochondrial disease (maternal, autosomal recessive, autosomal dominant, and X-linked) are highlighted in Table 2 , detailing their specific implications for recurrence risk to an affected individual's siblings and own future children

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