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El factor nuclear kappa B es factor de transcripcin que en estado inactivo est secuestrado en citoplasma unido a protenas inhibitorias, pero cuando clulas son expuestas a estrs oxidativo, a citocinas inflamatorias, o a otros estmulos, NF-kappaB es liberado y transloca a ncleo donde se une a secuencias especficas de ADN activando expresin de genes que codifican citocinas inflamatorias, enzimas que generan especies reactivas, molculas de adhesin, y mltiples otras protenas involucradas en respuestas de estrs