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Description

J.Turner-WarwickM

V.et al (2005)

Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4

A critical driver of AP pathogenesis was the dysregulated activation of the nucleotide oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, a cytosolic multiprotein complex that orchestrates caspase-1-mediated maturation of pro-inflammatory cytokines interleukin-1 (IL-1) and IL-18, as well as gasdermin D (GSDMD)-dependent pyroptotic cell death (Martinon et al., 2002)