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Mechanistically, the risk is attributed to the pharmacokinetic impact of piperine, which inhibits CYP3A4 and disrupts glucuronidation, increasing systemic curcumin exposure by over 20-fold and potentially converting otherwise safe doses into hepatotoxic levels in susceptible individuals

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By contrast, beneficial bacteria such as Bifidobacteria and Lactobacillus have low iron requirements [51] and create barriers against pathogen colonization in the gut [39]

Histological analysis on day 3 revealed characteristic inflammatory changes, including villus shortening and stromal thickening (crypt depth), as well as marked body weight loss (Fig