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However, some of the widely used affinity tags, such as the His-tag, exhibit several drawbacks and limitations, since they can increase the risk of distorting the natural conformation of the target protein or necessitate stringent elution and wash conditions affecting the yield of the target protein

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It is to explain what they are, what the physiology suggests, what the evidence shows, and where the risks sit

Consumers may not receive every proprietary technical detail, but a serious manufacturer should be able to explain how it verifies that the product is more than glutathione mixed with lecithin