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Hyperglycemia induces trained immunity in macrophages and their precursors and promotes atherosclerosis

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While neuroinflammation is an innate mechanism designed to protect against infections and injuries, chronic or dysregulated neuroinflammation contributes to the development and progression of CNS disorders ranging from early developmental disorders such as autism spectrum disorders (ASD) (Han et al., 2021) and schizophrenia (Mller et al., 2015) to neurogenerative disorders (Zhang et al., 2023) including Alzheimers and Parkinsons disease (Gella and Durany, 2009