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N501Y is a mutant variant emerging from the United Kingdom, South Africa and Brazil 50

The increase in Cho is believed to be related to a number of factors, including increased tumor cell density, increased membrane turnover, and altered Cho metabolism, in particular increased synthesis of PC in tumor cells [4, 5]

Preclinical models have demonstrated the potential of targeting the cGAS-STING axis and enhancing deoxyribonuclease 1-like 3 (DNase1L3) activity for the treatment of autoimmune diseases (19,45,46)