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The following tests help confirm the diagnosis: Slit-lamp examination of the eyes for Kayser-Fleischer rings Blood tests to measure levels of ceruloplasmin (a protein that transports copper through the bloodstream) Measurement of copper excreted in the urine If the diagnosis is still unclear, a liver biopsy Because early treatment is most effective, anyone who has a sibling, cousin, or parent with Wilson disease is tested for the disease

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Patched2 modulates tumorigenesis in patched1 heterozygous mice