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This diversity complicates the development of broad-spectrum senomorphic therapies.31 Senomorphic compounds that work effectively in one tissue might not produce the same results in others, requiring tailored or tissue-specific therapies.199 Regulatory Hurdles: Senomorphic therapies, particularly those derived from natural compounds (eg, resveratrol, curcumin), may face challenges in regulatory approval

But most people with Barretts esophagus will never develop these changes

Unlike neurons, which primarily generate ATP through oxidative phosphorylation, astrocytes predominantly rely on glycolysis for energy production

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