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In this context, Pennacchietti and colleagues showed that HGF inhibited the antitumor effects of Met-directed TKI and mAbs even in highly sensitive MET -amplified tumor cells (51)

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Conclusion The modified nano-product (TLR2 pep-orid-liposome) with structural encapsulation, efficiency enhancement and specific targeting of oridonin demonstrate the potential to a candidate for AML therapeutics

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