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Regulation of this response is facilitated by the antioxidant responsive element (ARE) which is located in the promoters of many of the genes that are induced by oxidative and chemical stress [47]

Researchers have established that lower GABA levels correlate with increased axon firing and energy needs in the sensorimotor cortex and hippocampus, perhaps leading to neuroaxonal degeneration in patients with MS with advanced disease [20]

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The results from the tail suspension test, as depicted in Figure 4, provide compelling evidence on the effects of different treatments on depressive-like behaviors in an animal model